{"type":"standard","title":"Dihydropteroate synthase","displaytitle":"Dihydropteroate synthase","namespace":{"id":0,"text":""},"wikibase_item":"Q5276443","titles":{"canonical":"Dihydropteroate_synthase","normalized":"Dihydropteroate synthase","display":"Dihydropteroate synthase"},"pageid":9268243,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/e/e9/THFsynthesispathway.png/320px-THFsynthesispathway.png","width":320,"height":201},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/e/e9/THFsynthesispathway.png","width":426,"height":267},"lang":"en","dir":"ltr","revision":"1198580754","tid":"42a93ba4-babe-11ee-8db4-689287c26374","timestamp":"2024-01-24T13:41:22Z","description":"Class of enzymes","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Dihydropteroate_synthase","revisions":"https://en.wikipedia.org/wiki/Dihydropteroate_synthase?action=history","edit":"https://en.wikipedia.org/wiki/Dihydropteroate_synthase?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Dihydropteroate_synthase"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Dihydropteroate_synthase","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Dihydropteroate_synthase","edit":"https://en.m.wikipedia.org/wiki/Dihydropteroate_synthase?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Dihydropteroate_synthase"}},"extract":"Dihydropteroate synthase (DHPS) is an enzyme classified under EC 2.5.1.15. It produces dihydropteroate in bacteria, but it is not expressed in most eukaryotes including humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor.(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate (PABA) diphosphate + dihydropteroate.","extract_html":"
Dihydropteroate synthase (DHPS) is an enzyme classified under EC 2.5.1.15. It produces dihydropteroate in bacteria, but it is not expressed in most eukaryotes including humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor.
- (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate (PABA)
diphosphate + dihydropteroate.
{"type":"programming","setup":"What did the Java code say to the C code?","punchline":"You've got no class.","id":380}
{"slip": { "id": 195, "advice": "Exercise in the rain can really make you feel alive."}}
{"fact":"A cat\u2019s back is extremely flexible because it has up to 53 loosely fitting vertebrae. Humans only have 34.","length":106}
{"slip": { "id": 46, "advice": "Try going commando to an important meeting, NB: don't wear a skirt."}}
{"type":"standard","title":"Ichime Glacier","displaytitle":"Ichime Glacier","namespace":{"id":0,"text":""},"wikibase_item":"Q5986216","titles":{"canonical":"Ichime_Glacier","normalized":"Ichime Glacier","display":"Ichime Glacier"},"pageid":16442694,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/1/1a/Antarctica%2C_Norway_territorial_claim_%28Queen_Maud_Land%2C_2015%29.svg/320px-Antarctica%2C_Norway_territorial_claim_%28Queen_Maud_Land%2C_2015%29.svg.png","width":320,"height":320},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/1/1a/Antarctica%2C_Norway_territorial_claim_%28Queen_Maud_Land%2C_2015%29.svg/806px-Antarctica%2C_Norway_territorial_claim_%28Queen_Maud_Land%2C_2015%29.svg.png","width":806,"height":806},"lang":"en","dir":"ltr","revision":"1075432517","tid":"1f04578b-9cb6-11ec-b0ab-e465c5c50dd9","timestamp":"2022-03-05T18:57:36Z","description":"Glacier in Antarctica","description_source":"local","coordinates":{"lat":-68.38333333,"lon":42.13333333},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Ichime_Glacier","revisions":"https://en.wikipedia.org/wiki/Ichime_Glacier?action=history","edit":"https://en.wikipedia.org/wiki/Ichime_Glacier?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Ichime_Glacier"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Ichime_Glacier","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Ichime_Glacier","edit":"https://en.m.wikipedia.org/wiki/Ichime_Glacier?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Ichime_Glacier"}},"extract":"Ichime Glacier is a glacier flowing to the sea just west of Kasumi Rock in Queen Maud Land, Antarctica. It was mapped from surveys and air photos by members of the Japanese Antarctic Research Expedition, 1957–1962, who also gave the glacier its name.","extract_html":"
Ichime Glacier is a glacier flowing to the sea just west of Kasumi Rock in Queen Maud Land, Antarctica. It was mapped from surveys and air photos by members of the Japanese Antarctic Research Expedition, 1957–1962, who also gave the glacier its name.
"}{"type":"standard","title":"Expedition 66","displaytitle":"Expedition 66","namespace":{"id":0,"text":""},"wikibase_item":"Q106453416","titles":{"canonical":"Expedition_66","normalized":"Expedition 66","display":"Expedition 66"},"pageid":65147573,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/db/Expedition_66_crew_poster.jpg/330px-Expedition_66_crew_poster.jpg","width":320,"height":213},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/d/db/Expedition_66_crew_poster.jpg","width":1800,"height":1200},"lang":"en","dir":"ltr","revision":"1253617104","tid":"de70350b-93f3-11ef-ad61-828e7c5c2ffd","timestamp":"2024-10-26T23:41:49Z","description":"Long-duration mission to the International Space Station","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Expedition_66","revisions":"https://en.wikipedia.org/wiki/Expedition_66?action=history","edit":"https://en.wikipedia.org/wiki/Expedition_66?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Expedition_66"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Expedition_66","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Expedition_66","edit":"https://en.m.wikipedia.org/wiki/Expedition_66?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Expedition_66"}},"extract":"Expedition 66 was the 66th long-duration expedition to the International Space Station. The mission began after the departure of Soyuz MS-18 on 17 October 2021. It was commanded by European Space Agency astronaut Thomas Pesquet, the fourth European astronaut and first French astronaut to command the ISS until 8 November 2021 when Russian cosmonaut Anton Shkaplerov, who arrived aboard Soyuz MS-19, took over his command.","extract_html":"
Expedition 66 was the 66th long-duration expedition to the International Space Station. The mission began after the departure of Soyuz MS-18 on 17 October 2021. It was commanded by European Space Agency astronaut Thomas Pesquet, the fourth European astronaut and first French astronaut to command the ISS until 8 November 2021 when Russian cosmonaut Anton Shkaplerov, who arrived aboard Soyuz MS-19, took over his command.
"}